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RESEARCH ARTICLE: Renalase is a novel, soluble monoamine
oxidase that regulates cardiac function
and blood pressure
The kidney not only regulates fluid and electrolyte balance but also functions as an endocrine organ. For
instance, it is the major source of circulating erythropoietin and renin. Despite currently available therapies,
there is a marked increase in cardiovascular morbidity and mortality among patients suffering from end-stage
renal disease. We hypothesized that the current understanding of the endocrine function of the kidney was
incomplete and that the organ might secrete additional proteins with important biological roles. Here we
report the identification of a novel flavin adenine dinucleotide–dependent amine oxidase (renalase) that is
secreted into the blood by the kidney and metabolizes catecholamines in vitro (renalase metabolizes dopamine
most efficiently, followed by epinephrine, and then norepinephrine)... READ MORE [PDF] >>
RESEARCH ARTICLE: Renalase gene is a novel susceptibility gene for essential hypertension: a two-stage association study in northern Han Chinese population
The discovery of Renalase may provide novel insights into the mechanisms of BP regulation and the pathogenesis of essential hypertension (EH). We designed a two-stage case-control study to investigate whether the renalase gene harbored any genetic variants associated with EH in the northern Han Chinese population...READ MORE [PDF] >>
REVIEW: Renalase, a new renal hormone: its role in health and disease
Renalase is a secreted amine oxidase that metabolizes
catecholamines. The approach used to identify this novel
renal hormone will be discussed, as will the experimental
data suggesting it regulates cardiovascular function, and its
deficiency contributes to heightened cardiovascular risks in
patients with chronic kidney disease. READ MORE [PDF] >>
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